Description
About NIMESULIDE+PARACETAMOL
NIMESULIDE+PARACETAMOL belongs to a class of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs). Pain can be temporary (acute) or long-lasting (chronic). Acute pain is caused by damage to the tissues of the muscle, bone or other organs for a short time. In contrast, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.
NIMESULIDE+PARACETAMOL is composed of two medicines: Nimesulide and Paracetamol. Together it relieves symptoms of arthritis, dysmenorrhea (painful periods or menstrual cramps) and reduce fever. Nimesulide is known to have an analgesic and anti-inflammatory effect for easing mild to moderate pain. It works by blocking the effect of a prostaglandin chemical responsible for inducing pain and inflammation in our bodies. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.
Take NIMESULIDE+PARACETAMOL exactly as directed by your doctor. The most common side effects of NIMESULIDE+PARACETAMOL are loss of appetite (in case of liver condition), nausea, vomiting, abdominal pain, persistent tiredness or dark/discoloured urine. It is not necessary for everyone to experience the above side effects. In case of any discomfort, speak with your doctor.
Do not take NIMESULIDE+PARACETAMOL if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. NIMESULIDE+PARACETAMOL may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects on taking this drug. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days.
Uses of NIMESULIDE+PARACETAMOL
Pain relief
Medicinal Benefits
NIMESULIDE+PARACETAMOL comprises nimesulide and paracetamol, primarily used to treat mild to moderate pain. NIMESULIDE+PARACETAMOL is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains. It helps treat pain by blocking the chemical messenger in the brain responsible for causing fever, pain and inflammation. Nimesulide works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting prostaglandin synthesis by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.
Directions for Use
Storage
Side Effects of NIMESULIDE+PARACETAMOL
- Nausea
- Vomiting
- Loss of appetite
- Abdominal pain
- Persistent tiredness
- Dark/discoloured urine
In-Depth Precautions and Warning
Drug Warnings
NIMESULIDE+PARACETAMOL is contraindicated in patients with a history of hypersensitivity (allergic) reaction to NIMESULIDE+PARACETAMOL, paracetamol, nimesulide, or other pain killers. Please inform your doctor before starting NIMESULIDE+PARACETAMOL if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in NIMESULIDE+PARACETAMOL is known to affect fertility, so if you are planning for pregnancy, contact the doctor. NIMESULIDE+PARACETAMOL should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take NIMESULIDE+PARACETAMOL as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.
Drug Interactions
Drug-Drug Interactions: NIMESULIDE+PARACETAMOL is shown to interact with various drugs. Some of them include lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, coumadin, aspirin), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), immune system affecting medicine (cyclosporine), cholesterol-reducing medicine (colestyramine) and antidepressants (duloxetine). These drugs may affect the working of NIMESULIDE+PARACETAMOL and may alter its efficacy.
Drug-Food Interactions: Excessive intake of alcoholic beverages, caffeine-containing food or drinks like coffee, tea, chocolate, and some fizzy drinks should be avoided while taking NIMESULIDE+PARACETAMOL. Taking together may lead to drowsiness and dizziness and sleepiness.
Drug-Disease Interactions: NIMESULIDE+PARACETAMOL should not recommend for people having bleeding disorders, like haemophilia, von Willebrand disease, or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.
Drug-Drug Interactions Checker List:
- LITHIUM
- METHOTREXATE
- WARFARIN
- COUMADIN
- ASPIRIN
- METOCLOPRAMIDE
- DOMPERIDONE
- FUROSEMIDE
- PREDNISONE
- CIPROFLOXACIN
- EPHEDRINE
- THEOPHYLLINE
- CYCLOSPORINE
- CHOLESTYRAMINE
- DULOXETINE
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