Description
Domperidone + Rabeprazole
Uses of Domperidone + Rabeprazole
- Domperidone + Rabeprazole is used in the treatment of Gastroesophageal Reflux Disease (GERD) when patients are not responding to Rabeprazole alone.
- It is also used in treating duodenal ulcers and gastric ulcers.
Side effects of Domperidone + Rabeprazole
- Sore throat
- Cough
- Abdominal pain
- Diarrhoea
- Flatulence
- Weakness
- Muscle pain
- Dizziness
How Domperidone + Rabeprazole works
- Domperidone, a dopamine antagonist with antiemetic properties, exhibits limited permeability through the blood-brain barrier. While extrapyramidal side effects are exceedingly rare in adult users, domperidone stimulates prolactin release from the pituitary. Its antiemetic efficacy may result from a blend of peripheral (gastrokinetic) actions and antagonism of dopamine receptors in the chemoreceptor trigger zone, situated beyond the blood-brain barrier in the area postrema.
- Rabeprazole is classified as an antisecretory agent, specifically a substituted benzimidazole proton-pump inhibitor, devoid of anticholinergic or histamine H2-receptor antagonist attributes. It suppresses gastric acid release by inhibiting the gastric H+ and K+ ATPase located at the secretory surface of the gastric parietal cell. Given that this enzyme functions as the acid (proton) pump within the parietal cell, rabeprazole is designated as a gastric proton pump inhibitor. Its mechanism involves blocking the ultimate stage of gastric acid secretion.
Expert Advice
Dosage Forms Available
- This combination is available for use via the oral route (delayed-release tablets and capsules).
Age and Dose Restrictions
- This combination is meant for adults and children above 18 years of age.
Contraindications
- Domperidone + Rabeprazole is contraindicated in patients with known allergies to domperidone or rabeprazole, and in patients who have prolactinoma and severe liver issues.
Other Medications To Avoid With This Medicine
- It is contraindicated to concurrently use anticoagulants (clopidogrel, warfarin), azole antifungals (ketoconazole, voriconazole, itraconazole, posaconazole), nucleoside reverse transcriptase inhibitors (atazanavir, amprenavir, nelfinavir), antacids (magnesium hydroxide, aluminium hydroxide, cimetidine), iron supplements, antibiotics (clarithromycin, erythromycin, ampicillin, rifampicin), cardiac medications (atropine, digoxin, amiodarone), antihypertensive agents (diltiazem), antineoplastic medications (methotrexate), and antiemetic medications (aprepitant) in combination with Domperidone + Rabeprazole. Consultation with a doctor is imperative before initiating any prescription or over-the-counter medications.
Overdose and Missed Dose
- Overdose of this combination can cause agitation, altered consciousness, convulsions, disorientation, somnolence, and extrapyramidal reactions. Inform your doctor regarding these effects and follow the advice accordingly.
- If you forget to take this combination, take it as soon as you remember, but avoid repeating the dose.
Use In Driving And Operating Machinery
- This combination may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy after taking this combination.
Use in Pregnancy and Lactation
- This combination is not recommended during pregnancy or breastfeeding.
Special Dietary & Lifestyle Recommendation
- Avoid alcohol when you are taking Domperidone + Rabeprazole.
- Individuals with gastroesophageal reflux disease should contemplate lifestyle adjustments, incorporating dietary modifications such as adopting a GERD-friendly diet characterised by an emphasis on low-acid foods, avoidance of spicy and fatty meals, and reduction of portion sizes, all in conjunction with the administration of Domperidone + Rabeprazole.
- It is best to take this combination before meals.
Reviews
There are no reviews yet.